During a stopover in Germany in the middle of a carefree road trip through Europe, two American girls find themselves alone at night when their car breaks down in the woods. Searching for help at a nearby villa, they are wooed into the clutches of a deranged retired surgeon who explains his mad scientific vision to his captives' utter horror. They are to be the subjects of his sick lifetime fantasy: to be the first to connect people, one to the next, and in doing so bring to life "the human centipede."
Inspired by the fictional Dr. Heiter, disturbed loner Martin dreams of creating a 12-person centipede and sets out to realize his sick fantasy.
Taking inspiration from The Human Centipede films, the warden of a notorious and troubled prison looks to create a 500-person human centipede as a solution to his problems.